Cetuximab is an epidermal growth factor receptor (EGFR) antagonist used for the treatment of:
Head and Neck Cancer:
Locally or regionally advanced squamous cell carcinoma of the head and neck along with radiation therapy.
Recurrent locoregional disease or metastatic squamous cell carcinoma of the head and neck along with platinum based therapy with fluorouracil.
Recurrent or metastatic squamous cell carcinoma of the head and neck progresses after platinum-based therapy.
K-Ras wild-type, EGFR-expressing, Metastatic Colorectal Cancer:
In conjunction with FOLFIRI for first-line treatment,
In conjunction with irinotecan in those who are refractory to irinotecan-based chemotherapy,
As a monotherapy in those who have failed oxaliplatin- and irinotecan-based chemotherapy or who are intolerant to irinotecan.
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