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NEXAVAR 200 MG ( SORAFENIB )

4.0 83000.0 7.78% off

Specifications

  • Product Types:   Anti Cancer
  • Health Benefits:   Cancer
  • Target Audience:   5+
  • Dosage:   200mg
  • Form:   Tablet

Descriptions

Renal Cell Carcinoma
Indicated for advanced renal cell carcinoma

400 mg PO q12hr

If skin toxicity, discontinue/decrease dose frequency to qDay or every other day as recommended by Manufacturer

Hepatocellular Carcinoma
Indicated for unresectable hepatocellular carcinoma

400 mg PO q12hr

If skin toxicity, discontinue/decrease dose frequency to qDay or every other day as recommended by Manufacturer

Thyroid Cancer
Indicated for locally recurrent or metastatic, progressive, differentiated thyroid cancer (DTC) that is refractory to radioactive iodine treatment

400 mg PO q12hr

Dosage modification for DTC

Dose reduction for dermatologic toxicities (see prescribing information for specific toxicity grades 2 or 3 dosage modifications)
First dose reduction: 600 mg/day (divided as 2 doses of 400 mg and 200 mg 12 hr apart)
Second dose reduction: 200 mg q12hr
Third dose reduction: 200 mg qDay
Dosage Modifications
Dermatologic toxicities (HCC or RCC)

Grade 1
Any occurrence: Continue treatment and consider topical therapy for symptomatic relief

Grade 2
First occurrence: Continue treatment and consider topical therapy for symptomatic relief; if no improvement within 7 days, interrupt treatment and decrease dose (see below)
No improvement within 7 days or second or third occurrence: Withhold drug until toxicity resolves to grade 0-1, then decrease dose by 1 level (ie, 400 mg daily or 400 mg every7 other day)
Fourth occurrence: Discontinue
Grade 3
First or second occurrence: Withhold drug until toxicity resolves to grade 0-1, then decrease dose by 1 level (ie, 400 mg daily or 400 mg every7 other day)
Third occurrence: Discontinue
Dermatologic toxicities (DTC)

Dose reduction schedule
First reduction to 600 mg/day: 400 mg and 200 mg administered 12 h apart
Second reduction to 400 mg/day: 200 mg q12hr
Third reduction to 200 mg/day: 200 mg once daily
Grade 1
Any occurrence: Continue treatment

Grade 2
First occurrence: Decrease dose to 600 mg/day; if no improvement, see below
No improvement within 7 days at reduced dose or second occurrence: Withhold drug until toxicity resolves to grade 1; if drug resumed, decrease dose per schedule
Third occurrence: Withhold drug until toxicity resolves to grade 1; if drug resumed, decrease dose per schedule
Fourth occurrence: Discontinue
Grade 3
First occurrence: Withhold drug until toxicity resolves to grade 1; if drug resumed, decrease dose by 1 dose level
Second occurrence: Withhold drug until toxicity resolves to grade 1; if drug resumed, decrease dose by 2 dose levels
Third occurrence: Discontinue

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Selling by

LEE PHARMA LIMITED

LEE PHARMA LIMITED

Join on 2026-02-22

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