Orlistat is a lipase inhibitor that comes in a capsule. It works by blocking the enzyme that breaks down fats consumed through food, inhibiting the absorption of dietary fats.
Undigested fat is then passed through the body. It is intended for use with a reduced-calorie diet and is also indicated to reduce the risk of weight regain.
Some patients may lose about 5% of their body weight. Dosage is one 120 mg capsule three times a day with each main meal containing fat (during or up to one hour after the meal).
An over-the-counter formulation is available at 60 mg capsules with each fat-containing meal. The most common adverse reactions to orlistat are oily discharge from the rectum, flatus with discharge, increased defecation, and fecal incontinence.
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