Topiramate can be combined with phentermine to decrease appetite and cravings. Combining the two drugs increases efficacy.
Adults with migraines and obesity are good candidates for this weight-loss medication. Some patients may lose an average of 5–10% of body weight. If more than 5% weight loss is not achieved after 12 weeks of the maximum dose, the weight loss pill should be gradually discontinued.
Daily doses with four strengths start at 3.75 mg/23 mg to 15 mg/92 mg. Side effects include abnormal sensations, dizziness, altered taste, insomnia, constipation, and dry mouth. Contraindications include uncontrolled hypertension and coronary artery disease, hyperthyroidism, glaucoma, and sensitivity to stimulants.
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